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Corticosteroid hormones are essential drugs for many patients. Sometimes a person, for some reason, cannot purchase these medicines at the pharmacy. Then the Internet comes to the rescue. If you are worried “Where can I buy cheap prednisolone online” – know that the easiest solution to this problem is to compare prices in different pharmacies.
Instructions for use
The present prednisolone in its characteristics prednisolone is extremely close to the “standard” of all glucocorticosteroids prednisolone. It has anti-allergic, anti-inflammatory, immunosuppressive and anti-shock effects.
Interaction with intracellular glucocorticoid receptors leads to the formation of dimers of the glucocorticoid-glucocorticoid receptor complex.
The complex of the steroid hormone with the receptor is transported into the cell nucleus. In the nucleus, this complex interacts with effector elements localized on the acceptor regions of chromatin (genes).
The anti-inflammatory effect of prednisolone is due to several factors.
- The drug induces the synthesis of lipocortin, which inhibits the activity of phospholipase A2. Inhibition of phospholipase A2-mediated hydrolysis of membrane phospholipids in damaged tissues prevents the formation of arachidonic acid.
- The anti-inflammatory effect of glucocorticoids is potentiated by their ability to inhibit the expression of COX-2 genes, which also leads to a decrease in the synthesis of prostaglandins in the inflammatory focus, including the pro-inflammatory prostaglandins E2 and I2.
- Prednisolone inhibits the expression of intercellular adhesion molecules in the endothelium of blood vessels, disrupting the penetration of neutrophils and monocytes into the inflammatory focus. After the administration of glucocorticoids, an increase in the concentration of neutrophils in the blood is noted. This causes a decrease in the number of neutrophils at the site of inflammation.
The immunosuppressive effect is due to the inhibition of transcription of DNA encoding the major histocompatibility complex, proinflammatory cytokines and inhibition of the proliferation of T-lymphocytes.
Antiallergic effect is associated with inhibition of the synthesis of allergy mediators, degranulation of mast cells and the release of allergy mediators, and therefore it is effective in allergic reactions of an immediate type.
Restores the sensitivity of adrenergic receptors to catecholamines. It accelerates the breakdown of proteins and reduces their concentration in plasma, inhibits the utilization of glucose by peripheral tissues and stimulates gluconeogenesis in the liver, potentiates the formation of enzyme proteins in the liver, erythropoietin, fibrinogen, surfactant, lipomodulin. It leads to the redistribution of fat, increases the formation of triglycerides and higher fatty acids. Reduces absorption and potentiates calcium excretion; retains sodium and water.
The mechanism of the anti-shock effect of prednisolone is associated with a decrease in the synthesis of a platelet activating factor (a shock mediator), as well as with a decrease in extraneuronal uptake and an increase in the pressor effect of catecholamines.
You can find cheap Prednisolone 5mg tablets, 30mg / ml ampoules – 1ml, 0.5% ointment.
Where to Buy Prednisolone Online
You can buy prednisolone online without a prescription – this drug is sold freely in many countries. If you still need to provide the online seller with confirmation of the doctor’s appointments, take their photo or scan in high resolution. Usually, this will be enough to acquire the steroid hormone. There are several analogues of prednisolone generics that you can buy online:
- Rectodelt;
- Prednisolone;
- Methylprednisolone.
