Patented STRaman (See-Through-Raman) technology is a newly developed Raman technique to identify chemical species nondestructively beneath diffusely scattering packaging material such as plastics or tablet coatings. Molecular spectroscopic technique Raman spectroscopy is a well-established molecular spectroscopic technique for noninvasive and nondestructive chemical analysis. It is used to identify mostly organic...Read More

Near-infrared spectroscopy is based on the absorption of radiation. This versatile technique makes possible the simultaneous determination of substances (active pharmaceutical ingredients, excipients and contaminants) on the one hand, and permits the convenient monitoring of processes such as mixing, granulation and drying on the other.Read More

Vis-NIR analytical technique enables significant cost and time savings compared to standard reference analysis. Pharmaceutical quality control is an indispensable part of the pharmaceutical manufacturing process. One of the key quality parameters that has to be determined is the uniformity of dosage units. The pharmaceutical manufacturer has to ensure the...Read More

Zinc oxide is used in various skin care creams, drugs, and drug products. «Zinc Determination» monograph includes ion chromatography USP has updated the General Chapter <591> «Zinc Determination» monograph to include ion chromatography as the preferred method for measuring zinc oxide. USP 41–NF 36 was developed in partnership with Metrohm...Read More

The Mira P is fast, easy, and accurate helping users optimize the inspection of incoming goods, formulation verification, and process monitoring. Mira P for the pharmaceutical industry: Instant onsite verification of raw materials Metrohm is introducing the latest compliant handheld Raman solution for the pharmaceutical industry. Mira P offers enhanced...Read More

Which titration suits your requirements best? Surfactant analysis does not follow the standard titration application profile. Anionic surfactant, cation surfactant, non-ionic surfactant, dual-phase titration; each has it’s own intricacy and fine-tuning. It is enough to make your head spin. Where do you start for the best analysis method? How do...Read More

Correlation plot of the predicted Heparin sodium product strength by NIRS versus the laboratory values. Displayed are the training data (blue) and validation data (turquois). Heparin is a glycosaminoglycan used as an anticoagulant for therapeutic uses. It can either be used directly for humans given by injection or used as...Read More

High standards require the most accurate analysis.  That’s where DIA stands apart from other techniques! Higher resolution, better sensitivity, and excellent reproducibility: this is how Dynamic Image Analysis (DIA) improves the characterisation of powders and granulates in both quality control and R&D. This white paper outlines how particle size distribution...Read More

The purity of a solvent (dichloromethane/methylene chloride) is monitored by NIR spectroscopy along with two of the major impurities (methanol and water). Recovering solvents The solvents that are used in manufacturing processes are often not disposed of or incinerated, but instead recovered and purified, as this saves considerable costs. Distillation...Read More

Sometimes size does matter. Due to matrix complications, detection limit requirements and standard methods, pulsed ammperometric detectors, PADs, are common feature of ion chromatography in the pharmaceutical laboratory. A key benefit of the PAD is its selective nature. Along with the expected chromatography variations in columns and mobile phases, the...Read More

Cleaning electrodes getting you down? Relax, the Solvotrode easyClean is here to help. Non-aqueous titrations have a habit of producing gluggy, gelatinous messes that take forever to clean from an electrode. For regular non-aqueous electrodes this means blocked membranes and low electrolyte flow, which in turn leads to slow responses,...Read More

Metrohm near-infrared spectrometer in diffuse reflection mode is ideal for determining the residual moisture in a lyophilized pharmaceutical product. Analysis of residual moisture in a lyophilised pharmaceutical product by near-infrared spectroscopy (NIRS) Quantification of residual moisture in lyophilised parenteral products is an important measurement in the pharmaceutical industry. Analyses are...Read More